A pill to stop drinking alcohol - Antabuse 500mg
- • How does Antabuse 500mg help with alcoholism?
- • Antabuse treatment for alcoholism
- • Buy Antabuse 500mg online
- • Antabuse 500mg forms of release online
- • Antabuse Indications
- • Antabuse 500mg Mechanism of action
- • Antabuse Instructions for use
- • Antabuse Contraindications
- • Antabuse Side effects
- • Antabuse Reviews
How does Antabuse 500mg help with alcoholism?
Antabuse treatment for alcoholism
The treatment of chronic alcoholism with Antabuse is based on sensitization. After using the medicine, the patient develops alcohol intolerance. The method is fraught with serious complications, so it is necessary to pass a diagnosis in the clinic and consult a doctor.
At home, the Antabuse is taken inside as a drink made from water and an effervescent tablet. It is also possible to conduct the filing with a special tablet or intramuscular injections with a gel.
Over time, the effectiveness of the drug is reduced, so supportive treatment is needed. The patient should take the pill every day.
It is inadmissible to give an Antabuse to a person without his knowledge. Treatment should be voluntary, otherwise, the patient may consume alcohol. Antabuse reacts with ethanol, which leads to the strongest intoxication of the body.
Antabuse does not cure the causes of alcoholism, and against the background of its intake, craving for alcohol remains. The drug only supports the patient in his decision to give up a bad habit.
Buy Antabuse 500mg online
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Antabuse 500mg forms of release online
Antabuse for alcoholism: Forms of the preparation.
The drug is produced in three forms:
- effervescent tablets for dilution in water;
- tablets for filings under the skin;
- gels for intramuscular injection.
The active substance of Antabuse is disulfiram. Still in its composition are: corn starch, tartaric acid, povidone, sodium hydrogen carbonate, colloidal silicon dioxide, microcrystalline cellulose, magnesium stearate and talc.
Antabuse is prescribed to patients with the purpose of treatment of alcoholism and prevention of relapses.
Antabuse 500mg Mechanism of action
The action of the Antabuse 500mg is achieved through disulfiram. It was first used in the process of manufacturing rubber. At some point, it turned out that workers in such industries are less likely to suffer from alcoholism than other people.
In the late 1940's. disulfiram began to be actively used for medical purposes. It interferes with the metabolism of alcohol, due to which the therapeutic effect is achieved.
The hepatic enzyme dehydrogenase converts ethanol to the aldehyde. Then it is converted to acetate under the influence of oxidoreductase, but the Antabuse 500 blocks its action.
As a result, a highly toxic aldehyde begins to accumulate in the body, leading to poisoning with characteristic symptoms:
- nausea and vomiting;
- a headache;
- shortness of breath;
- a decrease in pressure.
Having connected deterioration of the state of health with alcohol drinking, the patient starts to refuse consciously of the predilection. It forms an aversion to the taste and smell of vodka at the conditioned reflex level.
The effectiveness of the Antabuse 500mg is not due to a real disease, but to its threat, which is felt by an alcohol dependent. This is confirmed by the results of the research: 25% of people who received a pacifier for a whole year in confidence that they are treated with the drug, stopped drinking alcohol, and the same number of people refused to be addicted to this medication.
Antabuse Instructions for use
1-3 days before the start of Antabuse, a person should stop drinking alcohol. The exact time of abstinence is determined by the doctor on the basis of diagnosis and individual characteristics of the person. Also, the doctor warns the patient about the risks of drinking during treatment.
Effervescent tablets are diluted in 0.5 glasses of clean water. Drink it 1-2 times a day. Single dose - from 200 to 500 mg.
When from the beginning of the reception of Antabuse passes 7-10 days, the doctor gives the patient to drink 500 mg of medicine, and after that - 20-30 ml of vodka. After 1-2 days, the experiment is repeated in the hospital, after another 3-5 days - outpatient.
After the development of persistent conditioned reflex rejection of alcohol, it is necessary to continue supporting therapy with Antabuse. Its duration is 1-3 years. During this period, the daily dose of the drug should be 150-200 mg.
For coding from alcoholism, special tablets of the drug are sewn under the skin, the gel is injected intramuscularly. These procedures can only be performed by a doctor in the clinic.
Alcohol is also prohibited before coding. After it is carried out, the patient is immediately given a drink of alcohol for a clear demonstration of intoxication, which is caused by the reaction of disulfiram with ethanol. Doses of drugs are selected individually, the timing of the coding is different in each case.
Antabuse is strictly forbidden to use for hypersensitivity to disulfiram, during pregnancy, breastfeeding, as well as in cases when the patient is diagnosed with any diseases from the following list:
- severe cardiovascular pathologies;
- auditory or optic neuritis;
- a severe form of liver failure;
- disorders of hematopoiesis;
- pulmonary emphysema;
- bronchial asthma;
- convulsions of any origin;
- mental disorders;
- peptic ulcer in acute form;
- impaired renal - function;
Relative contraindications to Antabuse treatment are:
- compensated diseases of the heart and blood vessels;
- age from 60 years;
- recovery after a stomach ulcer or 12 - duodenal ulcers;
- residual effects after circulatory disorders in the brain;
- disulfiram psychoses in the anamnesis.
In these cases, the use of Antabuse is possible. The decision should be made by the doctor, assessing the possible risks and the expected effect of the treatment in a particular case.
Antabuse Side effects
Under the action of disulfiram on the body, the following can occur:
- metallic taste;
- polyneuritis of the legs;
- neuritis of the optic nerve;
- skin rash;
- confused consciousness;
- when colostomy - unpleasant odor (due to carbon sulfide);
- with nickel eczema - hepatitis.
As a result of combining Antabuse with alcoholic beverages, multiple complications from different organs and systems are likely.
Among the side effects:
- insufficiency of breathing;
- angina pectoris;
- myocardial infarction;
- cerebral edema;
- neurological disorders.
If a patient tries to mix vodka with alcohol, ignoring signs of intoxication and continuing to drink during treatment, he may have:
- pseudo-alcoholic psychoses;
- with cardiovascular pathologies - thrombosis;
- acute polyneuritis.
A combination with Antabuse more than 50-80 ml threatens a person with the severe heart, vascular, respiratory, convulsions, and swelling. At the first symptoms of poisoning, the patient is shown detoxification, taking analeptics and symptomatic therapy.
Antabuse 500mg: special instructions
The patient is necessarily warned about the danger of combining the drug with alcohol. If a person is simultaneously prescribed oral anticoagulants, he should often see a doctor. Doses of these drugs should be adjusted depending on the level of prothrombin, otherwise bleeding is possible.
With renal failure and hypothyroidism, Antabuse 500mg is used with caution. With severe kidney failure, the drug can not be used. The appointment of the Antabuse is unacceptable to minors and elderly patients.
Antabuse has structural analogs based on disulfiram.
With poor tolerance, disulfiram Antabuse can be replaced by Teturam and Radoter. These drugs have a similar effect, but at the heart of their effect lies Tetura. This substance also blocks the cleavage of the aldehyde, and upon contact with ethanol - causes severe intoxication.
Most of the interviewers say that at first, they did not believe in the severe consequences of mixing Antabuse with alcohol, which they frightened the doctor. They allowed themselves to drink a can of beer, but this provoked reddening of the face, a sudden increase in pressure, vomiting. These symptoms have helped many to strengthen the motivation for treatment.
Disulfiram-like reaction as a result of drinking a glass of vodka patients is compared with the state after drinking a liter of strong alcohol. They say that later the appearance of the bottle with alcohol begins to disgust.
It should be borne in mind that the reviews leave only those patients who have not yet degraded as a result of prolonged abuse of alcohol. In the late stages of dependence, as doctors say, even the strongest intoxication and risk of death do not stop people from drinking alcohol. They develop such a strong dependence that even if they want to be treated, they can not refrain from a glass.
Doctors also warn about the inadmissibility of drinking alcohol during treatment with Antabuse. Moreover, from alcohol, it is necessary to refuse already for 1-3 days prior to the beginning of reception of a preparation. This is a mandatory condition for which there are no exceptions.
Organisms are different for all people, doctors explain. In all people mixing Antabus with alcohol causes poisoning with nausea, pain in the head, a decrease in pressure, but the severity of the symptoms can not be predicted. Some people tolerate a disulfiram-like response better, for others - even 40 g of vodka taken during Antabuse treatment, creates a risk of death.